Complete Loss of EPCAM Immunoexpression Identifies EPCAM Deletion Carriers in MSH2-Negative Colorectal Neoplasia
نویسندگان
چکیده
منابع مشابه
Expression of EpCAM and EpCAM variants in human carcinomas
Tyrolean Cancer Research Institute, Innsbruck, Austria Oncotyrol—Center for Personalized Cancer Medicine, Innsbruck, Austria Department of Haematology and Oncology, Medical University of Innsbruck, Innsbruck, Austria Haemato-Oncological Day Hospital, Tappeiner Hospital, Merano, Italy Molecular Pathology Division, Institute of Pathology, University of Basel, Basel, Switzerland Department of Path...
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BACKGROUND Recent studies have revealed that a small subset of Lynch syndrome-associated colorectal carcinomas (CRCs) is caused by a germline EPCAM deletion-induced MSH2 epimutation. Based on the finding of this genetic alteration, we investigated the implications of EPCAM expression changes in microsatellite instability-high (MSI-H) CRCs. METHODS Expression of EPCAM and DNA mismatch repair p...
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We aimed to comprehensively investigate the clinicopathologic and molecular implications of altered epithelial cell adhesion molecule (EPCAM) expression in colorectal carcinoma (CRC). EPCAM immunohistochemical expression, EPCAM 3' end deletion, EPCAM promoter methylation, microsatellite instability (MSI), and the CpG island methylator phenotype (CIMP) were analyzed in large cohorts of human CRC...
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Long non-coding RNAs (lncRNAs) are involved in kinds of human diseases, including colorectal cancer (CRC). TINCR, a 3.7 kb long non coding RNA, was associated with cell differentiation in keratinocyte and gastric cancer cells. However, little is known about the role of TINCR in regulation CRC progression. Here, we showed that lncRNA TINCR was associated with CRC proliferation and metastasis. TI...
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ژورنال
عنوان ژورنال: Cancers
سال: 2020
ISSN: 2072-6694
DOI: 10.3390/cancers12102803